NEW YORK, Oct. 12, 2020 (GLOBE NEWSWIRE) — Avenue Therapeutics, Inc. (NASDAQ: ATXI) (“Avenue”), a company focused on the development of intravenous (“IV”) tramadol for the U.S. market, today announced it has received a Complete Response Letter (“CRL”) from the U.S. Food and Drug Administration (“FDA”) regarding the Company’s New Drug Application (“NDA”) for IV tramadol.

The CRL stated that although the pivotal Phase 3 clinical trials demonstrated statistically significant outcomes for all of the primary and many secondary endpoints, the FDA has determined that it cannot approve the application in its present form. The CRL stated that IV tramadol, intended to treat patients in acute pain who require an opioid, is not safe for the intended patient population. Specifically, if a patient requires an analgesic between the first dose of IV tramadol and the onset of analgesia, a rescue analgesic would be needed. The likely choice would be another

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El Fenix Mexican Restaurant on Lemmon Avenue in Dallas, near Inwood Road, has closed. It opened on Sept. 1, 1960, just over 60 years ago.

“We would like to thank our guests for over 60 years at our Lemmon location,” says Mike Karns, founder and CEO of El Fenix’s parent company, Local Favorite Restaurants. “Given current conditions, unfortunately we have made the difficult decision to not renew our lease.”

The company operates 14 El Fenix restaurants in Dallas-Fort Worth.

Beyond four stores in Dallas proper, the company sells its famous enchiladas at restaurants in Plano, Fort Worth, Arlington and more. (The El Fenix on Colorado Boulevard in North Oak Cliff was demolished in summer 2020 — a closure not related to the coronavirus pandemic. The landmark property was razed so a developer could build apartments in its place.)

The existing El Fenix restaurants offer takeout, curbside service and dine-in at

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KALAMAZOO — Another Ollie’s Bargain Outlet is opening in Southwest Michigan.



a sign above a store in a brick building: Ollie's Bargin Outlet located at 4425 S. Westnedge Ave. in Kalamazoo, Michigan on Friday, Sept. 18, 2020. The store is set to open on Wednesday, Sept. 30.


© Joel Bissell | jbissell@mlive.com/mlive.com/TNS
Ollie’s Bargin Outlet located at 4425 S. Westnedge Ave. in Kalamazoo, Michigan on Friday, Sept. 18, 2020. The store is set to open on Wednesday, Sept. 30.

Ollie’s Bargain Outlet is planning to open a Kalamazoo location at 9 a.m. on Wednesday, Sept. 30, near Lee’s Chicken, inside what used to be a Big Lots store at 4425 S Westnedge Ave., according to a news release.

The chain is one of the largest retailers of excess inventory and discounted product, calling itself the home of “Good Stuff Cheap,” mainly buying closeouts, package changes and discontinued merchandise, in order to sell it to customers for up to 70% off the original retail price, the release said.

The store sells books, toys, hardware, automotive, electronics — all offered at a discounted price — for what makes

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By Vittorio Bugatti

I’m a long-time express bus commuter and have helped to run a small business on Fifth Avenue in Midtown Manhattan for over ten years. Creating a busway along this historic thoroughfare is one of the best ideas I’ve heard in some time. It would be a win for businesses and customers alike, as I also patronize many of the stores on the aforementioned corridor.

Some retailers might oppose the plan because they’re afraid of lost revenue from clients that drive to their locations, however, I envision a Fifth Avenue that will be even more vibrant than it has been over the last several years, bustling with all the more shoppers, tourists, entrepreneurs, and office workers, because the reality is that most people here in New York City rely on

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State and City of Detroit officials have approved $6.1 million in economic development incentives to turn a 13-story residential hotel in downtown that recently housed lower and moderate-income tenants into an upscale Hilton hotel.



a store in a brick building: The former Park Avenue House in Detroit sits empty near Comerica Park just outside of downtown Detroit, photographed on Tuesday, Aug. 25, 2020.


© Kimberly P. Mitchell, Detroit Free Press
The former Park Avenue House in Detroit sits empty near Comerica Park just outside of downtown Detroit, photographed on Tuesday, Aug. 25, 2020.

The development group, Downtown Hospitality Detroit LLC, is planning a $50-million overhaul of the old Park Avenue House, 2305 Park Ave., to turn it into a 172-room “Tapestry Collection by Hilton” hotel featuring a first-floor restaurant and a cafe.

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The building would be renamed Royal Palm Hotel, which was its original name when it opened in 1924 as a Louis Kamper-designed property for prominent Detroit hotel developer Lew Tuller.

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The work of Councilman Michael Yun is continuing, even after his death.

Jersey City Mayor Steve Fulop announced Monday that the city will move forward with a project to create more parking for Central Avenue-area residents and businesses through a public-private partnership. The proposal, part of the Central Avenue 2901 Redevelopment Plan, will be discussed at the Planning Board meeting Tuesday.

The proposal calls for a new seven-story, mixed-use building and a multi-level parking garage with 400 public parking spaces on properties bordered by Central and Cambridge avenues and Griffith and Bowers streets. The plan also calls for 10,000-square-foot pedestrian plaza in the heart of the Heights neighborhood.

Yun, who died of COVID-19 in early April, and city officials spent nearly two years engaging the neighborhood and business community to craft an improved parking plan. Heights residents have long complained about the lack of parking.

“This is a project

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